In an era where the pursuit of health and longevity has become the ultimate luxury, a new breed of resorts is emerging, ...

mTOR is a protein. "[The mTORC1] pathway is thought to be responsible for cell growth and, when it is hyper-activated, it can ...

For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

The foundation has made strategic investments in biotech companies like Aeovian Pharmaceuticals, contributing $20 million to ...

A new review of the existing evidence shows how dietary interventions like keto, the Mediterranean diet, or intermittent ...

However, at pH 6.6, IL-2R signaling was only modestly impacted, and the MAPK/ERK pathway not at all. In contrast, at pH 6.6 we observed that both mTORC1 activation/signaling (as evaluated by ...

Since currently available agents mainly inhibit mTORC1, which may lead to an increase in Akt activity through loss of the negative feedback loop mediated by the PI3K pathway, new agents and ...

These key pathways are involved in insulin signaling and may directly enhance longevity and prevent age-related diseases. Holland said that “the mTORC1 and AMPK pathways are critical in ...

[9] Although less is known about this complex than mTORC1, two major functions have ... along with phosphorylation through the PI3K pathway, is required for full Akt activation.