For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

Purpose: The mechanism of action and pharmacokinetics of sirolimus when used as part of a drug-eluting stent (DES) and the efficacy and cost of using DESs versus bare-metal stents are discussed.

They chose the mTOR (mechanistic target of rapamycin) signaling pathway, which is known to regulate metabolism and growth in many cell types, as mTOR activation was observed in granulomas of ...

Metformin, a common medication used to treat type 2 diabetes, may also help reduce the viral reservoir in people living with ...

The study's findings reveal THC's role in influencing the mechanistic target of the rapamycin (mTOR) pathway, a crucial ...

Aadi Biosciences has instituted cash-saving measures after the company decided to halt the registrational Phase II PRECISION1 trial for its mTOR inhibitor, nab-sirolimus. The company’s decision ...

A study published in ACS Pharmacology & Translational Science indicated that long-term THC treatment can initially enhance ...

Charles Sawyers and colleagues have conducted a small early-stage clinical study to assess target modulation by the small-molecule inhibitor rapamycin. Rapamycin is approved to treat renal cancer ...

2010;67(24):2095-2106. Temsirolimus is primarily metabolized by the cytochrome P-450 (CYP) 3A4 isoenzyme to five major metabolites, with sirolimus being the principal active metabolite.

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving ...