However, the study published Aug. 28 in Nature Communications identifies the MYC gene as a common denominator across prostate cancers. The work demonstrates that initial MYC activation attracts ...

But the MYCN form of MYC may be easier to target because it is present only in tumours, and not in normal, cells. Now, several mTOR inhibitor drugs are entering paediatric clinical trials, to see how ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

A number of signaling pathways have been shown to be central to myeloma growth and survival including NFκB, MAPK, PI3K, JAK/STAT, MYC, MAF and the UPR. Molecules inhibiting these pathways have ...