Cancer cells are exposed to stress and depend on a balanced integrated stress response (ISR) to survive in the context of uncontrolled growth.

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

Shimon Amir received his PhD in Psychology from McGill University. After completing his postdoctoral training at the Center for Research on Drug Dependence, Concordia University, he joined the ...