Interplay and cooperation between SREBF1 and master ... - Nature
WEBJul 16, 2021 · Here, the authors show a transcriptional regulatory loop involving SREBF1, TP63 and KLF5 driving tumourigenesis in SCC through fatty acid, ERBB and mTOR pathway regulation.
Interplay and cooperation between SREBF1 and master …
WEBJul 16, 2021 · To further understand the alterations in the lipidome upon SREBF1-inhibition, we integrated RNA-Seq following SREBF1-inhibition (Supplementary Table 1) and its ChIP-Seq, and identified direct SREBF1 …
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in …
WEBImplications: The finding that an AR/mTOR complex promotes SREBF1 expression and activity enhances our understanding of the metabolic adaptation necessary for prostate cancer cell growth and suggests novel therapeutic approaches to target metabolic vulnerabilities in tumors.
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in …
WEBSep 4, 2018 · In the present study, we identified SREBF1 as a downstream target and integrator of the AR/mTOR transcriptional axis in prostate cancer cells. As such, both AR and mTOR are required to induce SREBF1 expression, and AR-mediated activation of mTOR is essential to promote SREBF1 processing, activation, and …
SREBP-regulated lipid metabolism: convergent physiology - Nature
WEBAug 29, 2017 · As mTOR was originally shown to promote protein synthesis in the liver, the hepatic mTOR–SREBP1 pathway is acknowledged as the molecular link between ER stress and lipid synthesis under...
SF3B3-regulated mTOR alternative splicing promotes colorectal …
WEBApr 26, 2024 · Mechanistically, silencing of SF3B3 increased mTOR exon-skipped splicing, leading to the suppression of lipogenesis via mTOR-SREBF1-FASN signaling. The combination of SF3B3 shRNAs and mTOR inhibitors showed synergistic antitumor activity in patient-derived CRC organoids and xenografts.
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis ...
WEBDec 8, 2020 · In conclusion, hyperactive mutation of PI3K-AKT-mTOR signaling protects cancer cells from oxidative stress and ferroptotic death through SREBP1/SCD1-mediated lipogenesis, and combination of mTORC1 inhibition with ferroptosis induction shows therapeutic promise in preclinical models.
Fatty acid metabolic reprogramming via mTOR-mediated ... - Nature
WEBNov 30, 2016 · Here, we show that the mTORC1–PPARγ pathway is crucial for the fatty acid uptake programme in activated CD4 + T cells. This pathway is required for full activation and rapid proliferation of naive...
SREBP Activity Is Regulated by mTORC1 and Contributes to
WEBOur results clearly implicate mTORC1 in the regulation of lipogenesis in epithelial cells. Silencing mTOR or raptor, but not rictor, is sufficient to abolish Akt-dependent incorporation of glucose, pyruvate, or acetate into cellular lipids.
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ... - PubMed
WEBDec 8, 2020 · Genetic or pharmacologic ablation of SREBP1 or SCD1 sensitized ferroptosis in cancer cells with PI3K-AKT-mTOR pathway mutation. Conversely, ectopic expression of SREPB1 or SCD1 restored ferroptosis resistance in these cells, even when mTORC1 was inhibited.