Sirolimus and mTOR Inhibitors: A Review of Side Effects and …
WEBThis article reviews the adverse effects of mTOR inhibitors in solid organ transplantation, with special attention given to mechanisms hypothesized to cause adverse events and their management strategies.
Targeting the biology of aging with mTOR inhibitors - Nature
WEBMay 4, 2023 · Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model...
Sirolimus and mTOR Inhibitors: A Review of Side Effects and
WEBMar 13, 2019 · Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative immunosuppressive drugs and have many clinical applications in various drug combinations.
Inhibition of the Mechanistic Target of Rapamycin (mTOR)–Rapamycin …
WEBIn this article, we discuss the molecular biology of mTOR, research into the mechanism by which mTOR inhibition promotes life span, the side effects of rapamycin, and possible ways in which rapamycin or alternative strategies to inhibit mTOR signaling may enable us to extend human life span and health span.
Game of TOR — The Target of Rapamycin Rules Four Kingdoms
WEBSep 28, 2017 · The mechanistic target of rapamycin, mTOR, is a downstream effector of many signaling pathways critical to human health. The 2017 Lasker Award for Basic Medical Research recognizes its discovery.
Multifaceted role of mTOR (mammalian target of rapamycin) …
WEBOct 2, 2023 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to...
mTOR inhibition with sirolimus in multiple system atrophy: a …
WEBMultiple system atrophy (MSA) is a rare neurodegenerative disease characterized by the aggregation of α-synuclein in glia and neurons. Sirolimus (rapamycin) is an mTOR inhibitor that promotes α-synuclein autophagy and reduces its associated neurotoxicity in …
Differentiating the mTOR inhibitors everolimus and sirolimus …
WEBAug 19, 2015 · Everolimus and sirolimus selectively inhibit mTOR signaling with similar molecular mechanisms, but with distinct clinical profiles. This review differentiates mTOR inhibitors in TSC while describing the molecular mechanisms, pathogenic mutations, and clinical trial outcomes for managing TSC.
miRNA375-3p/rapamycin mediates the mTOR pathway by …
WEB1 day ago · Rapamycin is an inhibitor of mTOR, which can promote autophagy by inhibiting the mTORC1 complex. As Fig. 3A–F indicates, Aβ25-35-induced decrease in Beclin1 and LC3B was caspase-dependent, which was evident by the significant increase in these proteins after the addition of the caspase inhibitor z-VAD-FMK, whereas the effects of the ...
Molecular actions of sirolimus: sirolimus and mTor - PubMed
WEBSirolimus targets a unique serine-threonine kinase, mammalian target of rapamycin (mTor), which plays a key role in mitogenic and nutritional cells signals. Within T cells, mTor regulates a number of proteins likely dependent on …
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