Sterol regulatory element-binding protein - Wikipedia
WEBOnce in the nucleus, SREBP can bind to specific DNA sequences (the sterol regulatory elements or SREs) that are found in the control regions of the genes that encode enzymes needed to make lipids. This binding to DNA leads to …
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
WEBSREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity.
The SREBP (Sterol Regulatory Element-Binding Protein) pathway: a ...
WEBOct 26, 2021 · The SREBP pathway in A mammals and B X. dendrorhous. The SREBP pathway is involved in the regulation of lipid homeostasis and metabolism, and is regulated by several independent mechanisms including the use of subcellular compartmentalization to ensure its activation, when required.
Sterol regulatory element binding protein 1 couples …
WEBMar 22, 2019 · Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several...
SREBP-regulated lipid metabolism: convergent physiology - Nature
WEBAug 29, 2017 · Sterol regulatory-element binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in lipid synthesis and function as key nodes of...
Review Sterol regulatory element-binding proteins (SREBPs ...
WEBNov 1, 2001 · SREBPs have unique characteristics. Firstly, they are membrane-bound proteins and the N-terminal active portions enter nucleus to activate their target genes after proteolytic cleavage, which requires sterol-sensing molecule, SREBP-activating protein (SCAP) and is crucial for sterol-regulation.
A pathway approach to investigate the function and regulation of …
WEBMar 21, 2013 · Sterol regulatory element-binding proteins (SREBPs) play an important role in the regulation of the intracellular cholesterol concentration and in overall lipid homeostasis.
Frontiers | Recent Insights Into SREBP as a Direct Mediator of …
WEBMar 16, 2020 · Public ChIP-seq data revealed numerous non-lipid transcriptional targets of SREBPs that plausibly play roles in progressive kidney disease and fibrosis. This review provides new insights into SREBP as a mediator of …
The cellular function of SCAP in metabolic signaling
WEBMay 8, 2020 · Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic...
SREBPs: metabolic integrators in physiology and metabolism
WEBFeb 1, 2012 · The phosphatidyl inositol-3-kinase (PI3K) and SREBP pathways intersect at multiple points, and recent insights demonstrate the importance of tight regulation of the PI3K pathway for regulating SREBPs in the adaptation to fluctuating dietary calorie load in the mammalian liver.