Pemphigus vulgaris pathology - DermNet
WEBHistology of pemphigus vulgaris. Early lesions of pemphigus vulgaris show suprabasal epidermal acantholysis, clefting and blister formation. The blister cavity may contain inflammatory cells including eosinophils and rounded acantholytic cells with intensely eosinophilic cytoplasm and a perinuclear halo.
Pemphigus Vulgaris - StatPearls - NCBI Bookshelf
WEBMar 1, 2024 · Pemphigus vulgaris is a rare autoimmune disease that causes blistering on cutaneous and mucosal surfaces. As the most prevalent type of pemphigus, its onset typically occurs between ages 40 and 60, affecting both genders equally.
Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris…
WEBJun 26, 2021 · Two common subtypes of pemphigus with distinct clinical and immunopathological features are characterized, i.e., Pemphigus Vulgaris (PV) and Pemphigus Foliaceus (PF) with PV comprises of approximately 70% …
Pathogenesis, clinical manifestations, and diagnosis of pemphigus
WEBJan 25, 2024 · Patients with pemphigus develop mucosal erosions and/or flaccid bullae, erosions, or pustules on skin. The four major entities of the pemphigus group include pemphigus vulgaris, pemphigus foliaceus, immunoglobulin A (IgA) pemphigus, and paraneoplastic pemphigus.
Comprehensive review on the pathophysiology, clinical variants …
WEBSep 20, 2021 · Pemphigus has distinct forms: pemphigus vulgaris (PV), pemphigus foliaceus (PF), paraneoplastic pemphigus (PNP), and IgA pemphigus. PV and PF are caused by a humoral autoimmune response, whereas PNP is caused by both humoral and cellular autoimmune responses ( 11 ).
Pemphigus: a Comprehensive Review on Pathogenesis, Clinical ...
WEBPemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and mucous membranes with high morbidity and potentially lethal outcome. The major clinical variant, pemphigus vulgaris (PV) is caused by a loss of intercellular adhesion of epidermal keratinocytes which is induced ….
Initial management of pemphigus vulgaris and pemphigus …
WEBJan 5, 2023 · The management of refractory pemphigus vulgaris and pemphigus foliaceus, the pathogenesis and diagnosis of pemphigus, and the diagnosis and management of paraneoplastic pemphigus and fogo selvagem (endemic pemphigus foliaceus) are …
Pemphigus Vulgaris - Mayo Clinic Proceedings
WEBClinicopathologic and serologic findings were consistent with pemphigus vulgaris. Pemphigus vulgaris, a potentially severe blistering autoimmune dermatosis characterized by flaccid blisters and erosions on the mucous membranes and/or skin, is caused by IgG4 autoantibodies directed against desmogleins on the surface of keratinocytes, leading to ...
Pathology - SpringerLink
WEBNov 27, 2017 · Detection of IgG antibodies by direct immunofluorescence is the gold standard test for diagnosis of pemphigus vulgaris. In this chapter, we will discuss the pathogenesis, morphologic, histomorphologic, and histopathology of pemphigus vulgaris and several diseases in the differential for PV.
Pemphigus Vulgaris - Pemphigus Vulgaris - MSD Manual Professional Edition
WEBKey Points. Pemphigus vulgaris is an uncommon, potentially fatal, autoimmune disorder characterized by intraepidermal blisters and extensive erosions on apparently healthy skin and mucous membranes. Diagnosis is by skin biopsy with direct and indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA) testing.